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DNA replication stress response involving PLK1, CDC6, POLQ, RAD51 and CLASPIN upregulation prognoses the outcome of early/mid-stage non-small cell lung cancer patients (2012)
Auteur(s): C. Allera-Moreau, I. Rouquette, B. Lepage, N. Oumouhou, V. Schelling, K. Gordien, L. Brouchet, J. Mazieres, M.B. Delisle, J.S. Hoffmann, P. Pasero and C. Cazaux

Lung cancer is the leading cause of cancer deaths worldwide. Clinical staging classification is generally insufficient to provide a reliable prognosis, particularly for early stages. In addition, prognostic factors are therefore needed to better forecast life expectancy and optimize adjuvant therapeutic strategy. Recent evidence indicates that alterations of the DNA replication program contribute...

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DNA synthesis by Pol η promotes fragile site stability by preventing under-replicated DNA in mitosis (2013)
Auteur(s): Valérie Bergoglio, Erin Walsh, Valeria Naïm, Anne-Sophie Boyer, Christophe Cazaux, Philippo Rosselli, Kristin Eckert and Jean-Sébastien Hoffmann

Human DNA polymerase η (Pol η) is best known for its role in responding to UV irradiation-induced genome damage. We have recently observed that Pol η is also required for the stability of common fragile sites (CFSs), whose rearrangements are considered a driving force of oncogenesis. Here, we explored the molecular mechanisms underlying this newly identified role. We demonstrated...

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DNA polymerase κ-dependent DNA synthesis at stalled replication forks is important for CHK1 activation (2013)
Auteur(s): Rémy Bétous, Marie-Jeanne Pillaire, Bénédicte Recolin, Katharina Steinmetz, Caixa Guo, Laura Pierini, Naoko Niimi, Petr Gruz, Takehiko Nohmi, Errol Friedberg, Christophe Cazaux, Domenico Maiorano and Jean-Sébastien Hoffmann

Formation of primed single-stranded DNA at stalled replication forks triggers activation of the replication checkpoint signalling cascade resulting in the ATR-mediated phosphorylation of the Chk1 protein kinase, thus preventing genomic instability. By using siRNA-mediated depletion in human cells and immunodepletion and reconstitution experiments in Xenopus egg extracts, we report that the...

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Comparative exponential proliferation of lymphoma cells (2013)
Auteur(s): Hamon A., Tosolini M., Ycart B., Pont F., Fournié JJ.

En cours de rédaction

Exponential growth of bifurcating processes with ancestral dependence (2013)
Auteur(s): Louhichi S., Ycart B.

Branching processes are classical growth models in cell kinetics. In their construction, it is usually assumed that cell lifetimes are independent random variables, which has been proved false in experiments. Models of dependent lifetimes are considered here, in particular bifurcating Markov chains. Under hypotheses of stationarity and multiplicative ergodicity, the corresponding branching...

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Letter counting: a stem cell for Cryptology, Quantitative Linguistics, and Statistics (2012)
Auteur(s): Ycart B.

Counting letters in written texts is a very ancient practice. It has accompanied the development of Cryptology, Quantitative Linguistics, and Statistics. In Cryptology, counting frequencies of the different characters in an encrypted message is the basis of the so called frequency analysis method. In Quantitative Linguistics, the proportion of vowels to consonants in different languages was...

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Alberti's letter counts (2012)
Auteur(s): Ycart B.

Four centuries before modern statistical linguistics was born, Leon Battista Alberti (1404--1472) compared the frequency of vowels in Latin poems and orations, making the first quantified observation of a stylistic difference ever. Using a corpus of 20 Latin texts (over 5 million letters), Alberti's observations are statistically assessed. Letter counts prove that poets used significantly more...

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Statistics for the Luria-Delbrück distribution (2012)
Auteur(s): Hamon A., Ycart B.

The Luria-Delbrück distribution is a classical model of mutations in cell kinetics. It is obtained as a limit when the probability of mutation tends to zero and the number of divisions to infinity. It can be interpreted as a compound Poisson distribution (for the number of mutations) of exponential mixtures (for the developing time of mutant clones) of geometric distributions (for the number of...

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Document(s) 1 à 8 sur 31 Suivant > >>
Version mobile Laboratoire d’Excellence Toulouse CancerLaboratoire d’Excellence Toulouse Cancer
Agenda

Cellular origin and mechanisms of pancreatic cancer
23/05/16 - Dr Axel Behrens - Auditorium IUCT-O - 10:00 - 11:00

Utilisation de l’imagerie in-vivo en temps réel dans l’étude de la motilité cellulaire
10/05/16 - Dr Erik Sahaï - Auditorium IUCT-O - 13:00 - 14:00
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Inserm CNRS Université Toulouse 3 - Paul Sabatier Université Joseph Fourier - Grenoble Agence Nationale de la Recherche Fondation RITC